Tobacco: Most Addictive substance

1. Tobacco is one of the most addictive substance known to human.
2. Nicotine is the principal psychoactive content of tobacco that maintains the addiction.
3. Nicotine exerts its pharmacological effect by binding to nicotinic acetylcholine receptors (nAChRs).
4. These ligand gated receptors are widely spread in the central nervous systems.
5. The most abundant nAChR subtypes are homomeric alpha 7 and hetermeric alpha 4 beta 2. Nicotine use by smoking or smokeless directly increases the dopamine in the ventral tegmental area (VTA ) by binding on alpha 4 beta 2 subunits located on dopamine cell bodies.
6. The dopamine-regulated mesocorticolimbic pathway from ventral tegmental area to nucleus accumbens and its projection to prefrontal cortex is the final reward pathway involved in various addictions.

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Video: Addictive Property of Tobacco

https://youtu.be/78qXnXjKjWY